The gold standard of evidence based medicine has many short-comings.
For a controlled trial to have any real meaning scientifically there
must be homoegenity in the sample as well as a definitive criteria in
identifying the problem state. Here we will examine the difficulties
in disease definition.

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Excerpted from : The controlled Clinical trial - An analysis
http://health.consumercide.com/tcctaa-hc.zip - for references cited
refer to Ebook
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Alvin Feinstein, M.D., professor at the Yale Medical School, has
commented extensively on
problems of disease definition in his classic Clinical Judgment and
other writings:
No other branch of natural...