[Feed restriction has extended lifespan in a wide variety of short lived
animal species. It had been assumed that the toxic effect of ad-libitum
feed consumption was due to excess calories. In the last several years
this assumption has been proven to be false. In nematodes, the benefit of
feed restriction is now ascribed to the restriction of coenzyme Q. In
drosophila, the benefit of feed restriction has been ascribed to protein
restriction. In mice, the benefit of feed restriction has been ascribed
to glycotoxin restriction. Over the years there have been a number of
failures in CR studies, where lifespan was not extended. These can be
explained, in the case of rodents, by a failure to control for glycotoxin
intake.]

[Glycotoxin content of rodent chow can be increased by roasting it at
high temperatures during sterilization. Rodents are adapted to consuming
only raw food in the wild, and they may be more vulnerable than humans to
the deletarious effects of Advanced Glycation End-products. Below serum
AGE levels closely predicted two year survival. Calorie intake by itself
was without effect. Note that glycotoxins are believed themselves to
affect body weight by influencing water retention.]

Diabetes June 2004 Volume 53 Supplement 2 A343 1426-P
Amelioration of Insulin Resistance, Weight Gain and Markers of Oxidant
Stress in Aging Mice by Dietary Glycotoxin Restriction: A Therapeutic
Alternative...

soowhatdouthink@hotmail.com wrote:

Doug,
Thanks for your interesting postings and original research.

You mentioned activated charcoal and AGEs. Can you supply a reference
to the rodent study below and to the Japanese Rx use? I have not been
able to find it.
[Can one reduce serum AGEs by means other than diet? Yes, activated
carbon can absorb AGEs, and this has increased lifespan in rodents. In
Japan a prescription activated carbon product has been used for years
in
the treatment of kidney failure patients. However the primary dietary
toxin specific for humans which is scavenged by this product may have
another source.]

Best wishes,
JLC

Paul Antonik Wakfer wrote:

...

jc101 wrote:

The product is AST-120 or Kremezin.
See PMID: 17088950 and 94 other hits for AST-120

MoreLife for the rational - http://morelife.org
Reality based tools for more life in quantity and quality
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Rational freedom by self-sovereignty & social contracting

Thanks, it looks like this Kremezin may be useful to reduce the CMLs
from the cooking of protein and fats, which is the source of the
largest exposure to AGEs for non-diabetics . I'm going to try to find
it in Japan, will be several years before it is a US drug.
PMID: 15051932 shows it reduces intima thickness.
One could use this with the poached salmon meal to protect from the
cooked protein damage/AGEs produced by the cooking process.
JLC

Paul Antonik Wakfer wrote:

There are some good ideas here, but the easiest and best thing to do is
to avoid any major source of unsaturated fatty acids, because then
there is no problem with lipid peroxidation. Nothing glycates proteins
like arachidonic acid, as the Fu study found. You could eat organic
purple olives (not cooking them), but all highly unsaturated oils are
all potentially very unhealthy, because there is no way to know if
"extra virgin, first cold pressed olive oil" is what the label says it
is. Recently, there has also been a lot of evidence on the damge and
dysfunction that oxidized cholesterol can cause, so that is something
to avoid as well. The problem is that there is a ludicrous "saturated
fat is bad" mantra in many nations. It is certainly true that lard, at
39%% saturated fatty acids, is...