Are you an administrator on your network? If not, your administrator may
have disabled your ability to make these changes. You are allowed to make
temporary changes of some sorts but the info is not written to the registry
so even these will not persist.

Also, do you have a PS2 mouse, a cordless mouse, or a USB mouse? If you have
either of the latter and it came with software, this software may be
controlling your mouse.

I had the same problem with a cordless mouse I bought. I ran the
installation CD and from then on I had to make changes through its
interface. I have since then uninstalled the software that came with the
mouse and can now configure it with Windows interface.

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