The best anti-malware solution for Mac OS X is a user who exercises a
modicum of caution and common sense. Don't download files from
questionable sources. Don't double-click e-mail attachments that you
didn't expect to get (and don't relax that practice for mail that
appears to come from friends and relatives). Don't run under an admin
account for day-to-day use and don't authenticate as an admin blindly
every time the prompt shows up on your screen.
Today, the best reason to run anti-malware software on a Mac is that
there's some authority figure with the power to tell you do so actually
doing so. For instance it may be a requirement for accessing a corporate
network. If you're in that situation, use <
http://www.clamxav.com/>. Any
time you're challenged to demonstrate that you're using up-to-date virus
protection, launch it, update the virus defs and take a screen shot (or
whatever evidence they want).