> Inhibition of HSV cell-to-cell spread by lactoferrin and
> lactoferricin.
> Jenssen H, Sandvik K, Andersen JH, Hancock RE, Gutteberg TJ Antiviral
> Res 2008 Apr 21.
>
> The milk protein lactoferrin (Lf) has multiple functions, including
> immune stimulation and antiviral activity towards herpes simplex virus
> 1 and 2 (HSV-1 and HSV-2); antiviral activity has also been reported
> for the N-terminal pepsin-derived fragment lactoferricin (Lfcin). The
> anti-HSV mode of action of Lf and Lfcin is assumed to involve, in
> part, their interaction with the cell surface glycosaminoglycan
> heparan sulfate, thereby blocking of viral entry. In this study we
> investigated the ability of human and bovine Lf and Lfcin to inhibit
> viral cell-to-cell spread as well as the involvement of cell surface
> glycosaminoglycans during viral cell-to-cell spread. Lf and Lfcin from
> both human and bovine origin, inhibited cell-to-cell spread of both
> HSV-1 and HSV-2. Inhibition of cell-to-cell spread by bovine Lfcin
> involved cell surface chondroitin sulfate. Based on transmission
> electron microscopy studies, human Lfcin, like bovine Lfcin, was
> randomly distributed intracellularly, thus differences in their
> antiviral activity could not be explained by differences in their
> distribution. In contrast, the cellular localization of iron-saturated
> (holo)-Lf appeared to differ from that of apo-Lf, indicating that
> holo- and apo-Lf may exhibit different antiviral mechanisms.
> Antiviral research [Antiviral Res]
> --------------------------------------------------------------------------------
>
>
> Who loves ya.
> Tom
>
>
> Jesus Was A Vegetarian!
> http://tinyurl.com/2r2nkh
>
>
> Man Is A Herbivore!
> http://tinyurl.com/a3cc3
>
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk
>
>