I once cycled to a job which was 2 miles away and 100 feet or so below
where I lived.

The reverse situation is perfect for cycle commuting: On cold winter
mornings you keep warm pedaling uphill and on hot summer afternoons
you keep cool coasting downhill.

Another situation combines use of a transit bus with cycling with the
wind. If you live downwind of your job take the bus upwind and then
cycle back with the wind. You aren't all sweaty and smelly when you
get to work and it also keeps your food bill / eating times down.

There must be others but I don't discover them until I'm there.

Bret Cahill