On Apr 25, 3:03 am, Jeff L
gmail.com> wrote:> Pixie wrote:
>> no, mr. brain box, there is a difference between being deoressed and
>> suicidal and what about all those clinical trials of HEALTHY
>> VOLUNTEERS?
>
> Sigh. Ignorant sow, they do not test anti-depressants on people who
> would, logically, have no need of antidepressants. They test them on
> people who have diagnosed clinical depression.
REALLY?? Well, I guess you know JACK SHIT ABOUT HOW TO GET A
MEDICATION APPROVED IN THE PHARMACEUTICAL INDUSTRY, do you??
Traci Johnson, oh sorry, i assumed that you could actually read
links.
>It wouldn't make any
> sense to test a drug on Joe Public, because Joe Public would respond
> quite differently.
WELL FUCK ME, PHASE I TRIALS OF DRUGS ARE INHERENTLY WRONG??
Phase I
Phase I trials are the first stage of testing in human subjects.
Normally, a small (20-80) group of HEALTHY volunteers will be
selected. This phase includes trials designed to assess the safety
(pharmacovigilance), tolerability, pharmacokinetics, and
pharmacodynamics of a drug. These trials are often conducted in an
inpatient clinic, where the subject can be observed by full-time
staff. The subject who receives the drug is usually observed until
several half-lives of the drug have passed. Phase I trials also
normally include dose-ranging, also called dose escalation, studies so
that the appropriate dose for therapeutic use can be found.
http://en.wikipedia.org/wiki/Clinical_trial#Phase_I
Read about clinical trials before you shoot off your mouth.
> Pixie wrote:
>> any abrupt change in dose (up or down) can result in suicide, psychosis or
>> hostility -- their word to describe homicide.
>
> Key word: Abrupt change. Under the monitoring of a qualified physician,
> this DOESN'T HAPPEN. Drugs are gradually increased, or decreased - NEVER
> abruptly started or stopped.
REALLY??
in many articles they state the the prozac LONG HALF LIFE MEANS YOU
CAN STOP COLD TURKEY, and doctors reflect this:
"The elimination half-life is long: 1-4 days for fluoxetine and 7-10
days for norfluoxetine. Because of the long half-life, the drug can be
administered once daily, efficacy is unaffected by an occasional
missed dose, and abrupt termination of therapy results in gradual
cessation of effects."
BULLSHIT it means you get delayed withdrawals. i wish you could read.
