Author: auto212951auto212951
Date: Dec 1, 2006 20:50
Hi everyone, and hopefuly buddy-Mobi
I know this has been chatted about to death, but i'm a freak for
details.
Heres the procedure as I understand it, and my questions:
Morphine is converted to H by heating it in a 3x mass equivalent of
acetic anhydride, for 6-8hrs at 85C. Assuming that proper lab equipment
was available, could a typical reflux setup be substituted for the
'clamped flask in the oven' method that seems to be common practice? i
mean, isnt this a little dangerous, what with lab glass being
exceptionally unstable under pressure? vaccuum sure, but Vogel had a
lot to say about never putting glassware under pressure.
After this 6-8 hr period has elapsed (any word on the best length of
time?), 2x the (volume of AA added) in water is added to convert
remaining AA into acetic acid. Finely powdered Na2Co3 is added until no
further effervesence is observed. This mixture is allowed to sit and
think for a while to allow complete precipitation of the desired base,
and then filtered to remove the precipitate. The ppte is then washed
with a small portion of cold h20 to remove excess Na2CO3.
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